The reduction of LC3-GFP puncta by diabetes was blocked by Prkca deletion (Fig. 4b).The decrease in conversion of LC3-I to LC3-II, a biochemical parameter for autophagy, was observed in embryos under diabetic conditions, and this decrease was abrogated in the absence of PKCα (Fig. 4c). The gene discussed is PRKCA; the disease is diabetes mellitus.