PRKCA and diabetes mellitus: miR-129-2 is downstream of PKCα because caPKCα simulated high glucose in upregulating miR-129-2 (Fig. 7k and Supplementary Fig. 4G), and siRNA knockdown of PKCα, or Prkca gene deletion blocked high glucose- or diabetes-increased miR-129-2 expression, respectively (Fig. 7l,m).