The mortality of PD patients was increased while they had increasing numbers of predictive factors including titers of IL-18 ≧ 804.3 pg/ml, titers of IL-6 ≧ 3.92 pg/ml, titers of IL-1ß ≧ 0.86 pg/ml, age ≧ 50 years-old, and diabetes. The gene discussed is IL18; the disease is diabetes mellitus.