ITGAM and infection: To evaluate whether this cell loss was due to lytic infection or to soluble factors like type I IFNs, which have been reported to be strongly induced early after infection 25, we repeated the infection in 129/Sv H2b wild type or 129/Sv‐IFNAR‐1−/− mice and observed that, in IFNAR‐1−/− mice, LDV did neither decrease the number of CD11b+ and CD8α+ cDCs (Fig. 5C and D) nor their ability to function as APC in MLC reactions using FVB (H2q) responder spleen cells (Fig. 5E).