CCN2 and neoplasm: Other key miRNAs affecting tumor angiogenesis are included in the miR-17–92 cluster, which encodes six mature miRNAs (miR-17, miR-18a, miR-19a, miR-20a, miR-19b, and miR-92a) and represses the levels of the anti-angiogenic molecules thrombospondin 1 (THBS1) and connective tissue growth factor (CTGF) [14].