HSPA1A and Insulin resistance: For instance, BGP-15 treatment resulted in HSPA1A/B (Hsp70) upregulation in rat and rabbit models of insulin resistance, dystrophic mice, and the VIDD rat model (Henstridge et al. 2014; Literáti-Nagy et al. 2014; Salah et al. 2016), while upregulation of DmHSP23 was observed in the Drosophila tachycardia model (Zhang et al. 2011).