HSP90AA1 and early-onset autosomal dominant Alzheimer disease: For instance, activation of HSF1 by the HSPC1 (Hsp90) inhibitor 17-(allylamino)geldanamycin (17-AAG) ameliorates cytotoxicity in an Alzheimer’s disease model (Chen et al. 2014), and activation of HSF1 by celastrol was shown to reduce toxicity in a cardiomyopathy model (Sharma et al. 2014).