IDH1 and neoplasm: Although nodular or ring-like enhancement in association with blood-brain barrier breakdown and angiogenesis [37, 42] is frequently observed in HGOs, it should be further noted that such enhancement patterns of HGOs are more homogenous than that of glioblastoma (WHO grade IV, most are IDH wild types), whereas it is quite difficult to stratify tumor grades by utilizing cMRI only.