To our knowledge, this is the first comprehensive meta-analysis investigating the possible correlations of SNPs rs16999593 (T/C), rs2228611 (G/A), and rs2228612 (A/G) in DNMT1 with risk of overall cancer and specific cancer types, which is anticipated to shed light on the role of DNMT1 polymorphisms in carcinogenesis. This evidence concerns the gene DNMT1 and cancer.