MAPT and Alzheimer disease: Alzheimer's disease (AD) is a progressive neurodegenerative disorder in the elderly that is characterized by progressive cognitive dysfunction [1], synaptic degeneration, neuronal loss, accumulation of amyloid-beta (Aβ) and neurofibrillary tangles (tau), and increased neuroinflammation which are the hallmarks of AD in the brain [2, 3].