In the study of expression profile of CRC, we found that high expression of MBD1 was closely related to genes in chromosomes 17P12 and 17P13 and the two chromosome zones included many known tumor suppressor genes, such as HIC1, VPS53, RPA1, ALOX15B, TP53, PFN1, MYBBP1A, and GABARAP. The gene discussed is VPS53; the disease is colorectal carcinoma.