Following hepatic secretion of apoC-III as VLDL, its subsequent distribution on HDL particles may also be harmful, since HDL-apoC-III predicted angiographic progression of atherosclerosis in bypass grafts [16] and more recently HDL-apoC-III has been identified as a proatherogenic HDL subtype with loss of its anti-inflammatory properties [16]. Here, APOC3 is linked to atherosclerosis.