INS and obesity due to melanocortin 4 receptor deficiency: Measures of obesity (BMI, waist circumference, and waist to height ratio), blood pressure (systolic and diastolic), glucose homeostasis (fasting glucose, insulin, and the homeostasis index), lipids, and apolipoproteins were different between individuals being MHO and MAO with the exception of TC, LDL-C, and HDL-apoC-III (Table 1).