Indeed, different types of ECM are composed of a great variety of molecules with various functional and structural properties, which give each type of ECM specific capabilities for regulating the function and development of cells.18 In the present study, it was revealed that a combination of laminin, collagen type IV, heparan sulfate proteoglycan and entactin, which were derived from Engelbreth-Holm-Swarm mouse sarcoma, modulated factors contributing to testosterone synthesis and thus impacted testosterone production. Here, LAMB2 is linked to sarcoma.