Compound K-2-11 could suppress also increase of ROS (caused by DOXO and further doxorubicin semiquinone radical initiated reduction of molecular oxygen and generation of superoxide radical, which initiates ROS production chain reaction), preventing in this way NF-κB activation that could consequently lead to a normal expression of MDR1 and antiapoptosis genes, restoring chemosensitivity of cancer cells. Here, NFKB1 is linked to cancer.