Consistent with the findings that Nrf2 is potentially involved in glaucoma, activation of endogenous Nrf2 pathway in the retinas using triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-imidazolide, a Nrf2 activator, promotes neuronal survival in both the retinal ischemia/reperfusion and the optic nerve injury models [163, 165]. Here, NFE2L2 is linked to retinal ischemia.