Furthermore, Tumor Necrosis Factor Alfa (TNF-α) activates MSCs to secrete chemokine (C-C motif) ligand 5 (CCL5), C-C chemokine receptor type 2 (CCR2), and the interleukin 8 receptor, beta (CXCR2) ligands that in turn recruit CXCR2+ neutrophils into the tumor. Here, CCR2 is linked to neoplasm.