Moreover, Th2 cells' interaction with the TME and particularly with MSCs inhibits immune rejection of the tumor (through the production of Interleukin-4, IL-4, Interleukin-5, IL-5, and Interleukin-13, IL-13) and promotes the presence of immunosuppressive type 2 macrophages [132–135]. The gene discussed is IL4; the disease is neoplasm.