In particular, we identified six genes (MAP2K4, PDLIM5, PPP2R5E, SNX13, GNAS, and FRS2) of high interest as novel T2D associated genes, as they all have additional support for being of relevance for islet biology or function from the islet biology gene sets and furthermore SNPs in the vicinity of these genes are associated with T2D or glycemic traits with P < 1 × 10−4 (Table 2). This evidence concerns the gene GNAS and type 2 diabetes mellitus.