In the present study, we divided the aged mice into the cognitive-normal mice and the cognitive-impaired mice by MWM, and we found that synaptic proteins, GluR1, GluR2, NR2A, NR2B, synaptophysin, and synaptotagmin1 in the hippocampus of the cognitive-impaired aging mice were significantly decreased compared to the cognitive-normal mice. This evidence concerns the gene GRIN2A and cognition.