HTR1A and Anxiety: Locally synthesized cholesterol is the precursor for neuro-steroids implied as potential mediators of anxiety in mammals (Gunn et al., 2011; Zorumski et al., 2013), augmenting GABAA signaling (Gunn et al., 2011) but also interacting with NMDAR (Paul et al., 2013) and 5-HT1A receptor (Sun et al., 2015).