In AD and various tauopathies, p-Tau accumulates intracellularly as filaments, pre-tangles, and insoluble NFTs, and hyper-reacts to anti-p-Tau-specific antibodies (Greenberg and Davies, 1990; Ballatore et al., 2007; Gendron and Petrucelli, 2009). This evidence concerns the gene MAPT and tauopathy.