To evaluate the effect of cryptolepine on mitochondrial biogenesis in melanoma cells, the levels of two mitochondrial proteins succinate dehydrogenase-A (SDH-A), which is a subunit of respiratory Complex II and encoded by nuclear DNA, and cytochrome c oxidase I (COX-I), which is a subunit of respiratory Complex IV and is encoded by mitochondrial DNA, were measured simultaneously using the MitoBiogenesisTM In-Cell ELISA Colorimetric system. This evidence concerns the gene MT-CO1 and melanoma.