GRN and Alzheimer disease: Biochemical features of accumulated tau in cases of GRN mutation (Fig. 5, Case 3: lane 1, Case 4: lane 2) were compared with those of other tauopathies including CBD (lane 3), PSP (lane 4) and AD (lane 5) by immunoblot analysis of the sarkosyl-insoluble fraction using C-terminal tau antibody (T46) (Fig. 5).