Furthermore, tau-positive astrocytic structures, resembling “bush-like” astrocytes previously reported in AGD33, were found in the cortex in all cases in Study A. Their morphology was significantly different from the tufted-astrocytes in progressive non-fluent aphasia (PSP) patients, the astrocytic plaques in corticobasal degeneration (CBD) or the ramified astrocytes in Pick’s disease (Fig. 2D). This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.