Here, we used a signal sequence (Psp) to release TGFα-PE38 with the aim of achieving greater anti-tumor effects than those obtained with a phage lysis system: in this case, simultaneous induction of both TGFα-PE38 and the phage lysis gene by a single inducible araBAD promoter would reduce the anti-tumor effect because the number of intra-tumoral Salmonellae decreased after each round of induction. Here, TGFA is linked to neoplasm.