TNFAIP3 and cirrhosis of liver: A number of studies have shown that A20 was significantly up-regulated in peripheral blood mononuclear cells of CHB and the progressive acute-on-chronic hepatitis B liver failure (ACHBLF), liver cirrhosis and HCC patients, and in the liver tissues of patients with nonalcoholic steatohepatitis (NASH) [23, 30, 31].