TCHP and glioma: Although there is no exact evidence of on nerve cells transformation after HCNV infection the specific detection of low levels HCMV in human gliomas raises the possibility that this latent infection could enhance the growth or survival of glioma On the other side glioma cells provide a genetic surroundings with features of disturbances signaling pathways, transcriptional factors and tumor suppressor proteins, that enables HCMV to exert its modulatory potential in tumor cells but not in normal cells [36].