The presenilin-1 group had greater volume loss in the thalamus bilaterally compared with the early-onset AD group (p<0.001 uncorrected), and around the cingulate gyrus in comparison with both the early-onset and late-onset AD group (p<0.05 FWE) and the DLB group (p<0.05 FWE). The gene discussed is PSEN1; the disease is Alzheimer disease.