Female mice that overexpress the gene for human SERT demonstrate PH.6 Lungs from serotonin transporter overexpressing (SERT+) mice demonstrated increased oxidative stress.25 The 5-HT1BR antagonist, SB216641, reduced the increase in right ventricular systolic pressure (RVSP) in SERT+ mice (Figure 5A), and as shown before,6 SERT+ mice show no change in right ventricular hypertrophy (RVH; Figure 5B). This evidence concerns the gene SLC6A4 and Right ventricular hypertrophy.