Differential protein expression levels through the LV suggest that longer term studies may be of value to determine whether, at more‐advanced time points, further changes to the BIN‐1‐JP2 protein axis leads to a critical tipping point that precipitates a more‐severe and more‐widespread t‐t structural phenotype, providing the impetus for hypocontractility and heart failure development. Here, BIN1 is linked to heart failure.