JPH2 and heart failure: Significantly, a recent study has shown that adeno‐associated virus‐mediated overexpression of JP2 (2.38±0.61‐fold increase in abundance) in mice with early‐stage heart failure leads to a suppression of Ca2+ leak through the RyR2 and a persevered t‐t organization compared to control groups.43 Therefore, our data now provide additional evidence to indicate that there may also be benefits for targeting JP2 expression in the setting of MI.