Junctophilin‐2 (JP2), connecting the t‐ts to the junctional sarcoplasmic reticulum, is central for maintaining dyad organization (sites of Ca2+ release)19, 20 and organization of t‐t geometry.21 Reduced cardiac expression of JP2 has been identified both in animal models and patients with heart failure.22, 23, 24, 25, 26 A recent study of the t‐t network in murine skeletal muscle cells reported that the Eps 15 homology domain protein, isoform 1 (EHD1), is important for maintaining t‐t integrity through an association with BIN‐1. This evidence concerns the gene BIN1 and heart failure.