Genome wide association studies (GWAS) have shown that SNPs in the CDKN2A locus (typified by rs10757274) and encompassed by ANRIL, but 94 KB downstream of the DMR discussed in this paper, were associated with increased susceptibility to frailty, coronary artery disease, myocardial infarction, type 2 diabetes and late onset Alzheimer disease (Melzer et al., 2007, Cunnington et al., 2010, Grarup et al., 2007, Zhuang et al., 2012, Zeggini et al., 2007, Scott et al., 2007, Broadbent et al., 2008, Congrains et al., 2012). This evidence concerns the gene CDKN2B-AS1 and type 2 diabetes mellitus.