It should be noted that there are reciprocal changes in the various EMT markers, namely E-cadherin, N-cadherin, Vimentin, and Snail, between MCF-7 o/e Snail cells and MCF-7 o/e Snail tissue (bone tissue), leading us to speculate that a reverse EMT, that is a MET, occurs during seeding of the tumor cells into the bone. The gene discussed is CDH2; the disease is neoplasm.