TNF and cancer: Therefore we quantified the amount of some pro-inflammatory cytokines (IL1β, TNFα, IL12-p70, IL6, IL8, IL10) by CBA and found that the SCM was highly enriched in IL6 and IL8 (Additional file 2: Figure S1B), two pleiotropic pro-inflammatory cytokines that have been implicated in cancer progression [32, 43].