DLG4 and early-onset autosomal dominant Alzheimer disease: A recent study on the effect of DHT on synapticplasticity of the hippocampus in male senescence-accelerated mouse prone 8 (SAMP8) mice (agood model of cognitive decline due to its similarities to Alzheimer’s disease) found thatDHT treatment promoted expression of synaptic plasticity markers [namely, cAMP-responseelement binding protein (CREB), postsynaptic density protein 95 (PSD95), synaptophysin(SYN), and developmentally regulated brain protein (Drebrin)], positively modifiedsynaptic structure, and significantly delayed cognitive impairment (215).