The SRD5A3 gene has also been linked to increased DHT production in hormonerefractory prostate cancer cells (12), and thisgene may be particularly important in metastatic prostate cells, which have been shown toexpress more SRD5A1 and SRD5A3 but significantly less SRD5A2 (13). This evidence concerns the gene SRD5A2 and prostate cancer.