As the phosphorylation/activity of STAT2 was increased in lesional psoriatic skin, and the expression of CXCL11 and CCL5 was found to be regulated through a STAT2-dependent mechanism in vitro, we next examined the expression level of CXCL11 and CCL5 in skin biopsies from 16 patients with psoriasis and from 6 healthy controls. The gene discussed is CCL5; the disease is psoriasis.