HMOX1 and neoplasm: Interestingly, in the UCHL1 KDs we found downregulation of additional proangiogenic genes such as ELK3, CXCL12, ANGPT1, HMOX1, or DLK1 and upregulation of the anti-angiogenic gene THBS1. UCHL1 has been shown to increase metastasis through deubiquitination and stabilization of HIF-1α, a central protein in tumor angiogenesis [17].