Within the list of top differentially expressed genes, in the UCHL1 KDs we found downregulation of the Wnt targets POSTN, SP7, and DLL1, of the transporter ABCA4, of the homeobox gene DLX4, and of genes recently linked to cancer progression ACTA2, AQ4, GRAP2, and ALK. The gene discussed is ABCA4; the disease is cancer.