The potential role of UCHL1 in modulating pathways involved in the niche of glioma CSCs such us angiogenesis, extracellular matrix-receptor interaction, or receptor endocytosis and intracellular trafficking, may point to promising targets for treatment in pediatric high-grade gliomas by either targeting directly UCHL1 or its associated pathways. Here, UCHL1 is linked to glioma.