However, in the both phases, no change was observed in fnbpA transcription between the PGE2-treated and un-treated S. aureus. The transcriptional results of fnbpA and fnbpB indicated that PGE2 can in part regulate the transcription of genes coding for fibronectin-binding proteins.Several observations supported that S. aureus colonization is significantly higher in some cancer patients than that in the healthy [62–64] and COX-2 appears as frequently upregulated in tumor cells [65,66]. The gene discussed is PTGS2; the disease is cancer.