The E2-mediated change in SAT insulin resistance was inversely correlated with the proportion of ERα/ERβ protein in the nuclear fraction (r = -0.431, P = 0.017; Fig 5A), but not the cytosolic fraction (r = 0.118, P = 0.535; Fig 5B) at baseline (placebo day). The gene discussed is ESR1; the disease is Insulin resistance.