This was done by exploring the global gene expression profiles in prostate tumor tissue, in prostate TINT, and in pre-metastatic regional LNs from rats carrying either of these two rat prostate tumors: 1) the locally aggressive, poorly differentiated, and low metastatic AT1-tumor, or 2) the locally aggressive, poorly differentiated and highly metastatic MatLyLu (MLL)-tumor (metastasizes primarily to lymph nodes and lung) [32]. This evidence concerns the gene KMT2A and prostate neoplasm.