In TINT surrounding the highly metastatic MLL-tumor we found multiple differently expressed genes encoding for proteins that are known to induce a tumor-promoting inflammation, a reactive stroma, and to promote invasion and metastasis (for example Clu, Figf, Ccl2, Ctgf, Mmp15, Mmp7, Grhl3, Plau, Anxa2, and Bmp2). This evidence concerns the gene ANXA2 and neoplasm.