Individual factors responsible for this could for example be increased CTLA4 and LAG3 (blocking anti-tumor immune responses [79]), downregulated CSF-1, CSF-1R, TNFSF11 and CD169 (resulting in decreased antigen presentation [84]), and downregulated CLEC1B and OSM (resulting in decreased recruitment of immune cells via high endothelial venules [80, 81, 91]). Here, SIGLEC1 is linked to neoplasm.