HMOX1 and cancer: Some factors already identified in the rat model—such as Hmox1, Lox, and Pdgfbr, and accumulation of inflammatory cells such as macrophages, myeloid suppressor cells and mast cells—were increased in the benign parts of the prostate in cancer patients and the magnitudes of these changes were related to patient outcome [9, 11, 13, 65, 97].