TRPV4 and familial hypocalciuric hypercalcemia: On the other hand, the lack of effect of pharmacological inhibitors of voltage-gated Ca2+ channel on the TRPV4 channel agonist GSK1016790A induced activation of KCa channel currents suggests that the TRPV4 channels native in FHH rat cerebral arterial myocytes could function as a voltage-independent Ca2+ entry pathway to regulate KCa channel current activity in these cells.