Furthermore, PD-L1 overexpresion was significantly associated with poor DFS/PFS in patients with hepatocellular carcinoma (HCC) (HR = 1.72, 95% CI = 1.21–2.46, P = .003), melanoma (HR = 3.39, 95% CI = 2.02–5.69, P <.000), and renal carcinoma, (HR = 5.04, 95% CI = 2.87–8.86, P <.000). The gene discussed is CD274; the disease is melanoma.