The DFS/PFS subgroup analysis showed that the PD-L1 overexpression was associated with shorter DFS/PFS in HCC (HR = 1.72, 95% CI = 1.21–2.46, P = .003), melanoma (HR = 3.39, 95% CI = 2.02–5.69, P <.000), and renal carcinoma, (HR = 5.04, 95% CI = 2.87–8.86, P <.000; Fig. 5, Table 2). This evidence concerns the gene CD274 and hepatocellular carcinoma.