A link between miR-1 and glycolysis was first reported by Wei et al. who showed that miR-1 repressed the heart fetal gene program by directly targeting estrogen-related receptor beta (Errβ), a principal regulator of glycolysis and glycogenesis.21 This discovery may be relevant to understanding mechanisms of oncogenesis, as miR-1 is a well-known tumor suppressor, acting by inhibition of multiple targets, including TAGLN2, CCND2, CXCR4 and SDF-1R,22, 23, 24, 25, 26 which play key roles in tumor progression. Here, CCND2 is linked to neoplasm.