HK2 and neoplasm: The glycolytic pathway comprises a series of 10 metabolic reactions catalyzed by multiple enzymes or enzyme complexes, including hexokinases and phosphofructokinases, such as HK2 and PFKP, whose expression is often increased in tumor cells, resulting in a rapid shift from glucose uptake to lactate production.2 Accumulation of lactate in tumor microenvironment contributes to immune escape, migration, tumorigenesis and angiogenesis,3 suggesting a functional role of the Warburg effect in tumor progression.