PDK1 and colorectal cancer: HIF-1α target genes include glucose transporters that increase glucose uptake and pyruvate dehydrogenase kinases (PDK1–3) that shunt pyruvate away from mitochondria through the inhibition of pyruvate dehydrogenase.45, 46, 47, 48, 49 In this study, we found that HIF-1α was a direct functional target of miR-1 in human colorectal cancer.