Interestingly, HIF-1α, well known for its role in tumorigenesis and tumor progression, is a critical regulator in regulation of HK2 and MCT4 during tumor Warburg27, 28 and we also found that miR-1 had an effect on HK2, HIF-1α and MCT4 mRNA expression levels (Figures 3b, d and f), indicating that these glycolytic metabolic enzymes were regulated by miR-1 may not only at mRNA transcriptional level but also at protein expression level. The gene discussed is HK2; the disease is neoplasm.