NFKB1 and lung carcinoma: Overall, based on these results, we concluded that miR-18a-5p could drive cancer by directly targeting IRF2 (Figure 7), and might also have a close correlation between the p53 and NF-κB signalling pathway (Supplementary Figure S3).39, 40, 41 Our findings provided a potential understanding of the mechanism how miRNAs affect the oncogenesis of lung cancer, which could be employed as drug targets for diagnostics and therapeutic treatments in the future.