The EGFR is an important factor involved in the progression of NSCLC.30, 31 EGFR affects numerous systems involved in oncogenesis.32 It has been proposed as an attractive and promising target for anti-cancer treatment.33 In our cases, overexpression of miR-18a was upregulation of autophagy and positive correlation with expression of EGFR in vivo. The gene discussed is EGFR; the disease is cancer.