Our previous study confirmed that IKZF1 plays an important role in HCC.30 Additionally, IKZF1 bound to the regulatory regions of MYC and suppressed MYC expression in acute lymphoblastic leukemia cells.36 In the current study, we show that in HCC cell lines, MDIG levels are decreased by overexpression of IKZF1. This evidence concerns the gene RIOX2 and acute lymphoblastic leukemia.