RIOX2 and lung cancer: For instance, overexpression of MDIG is associated with high metastatic potential, positive lymph node metastasis and shorter Overall Survival (OS) in gastric cancer patients.25, 26 However, a paradoxical effect of MDIG on cell growth and motility at different stages of neoplastic transformation in non-small cell lung cancer has also been suggested.31 MDIG overexpression was also correlated with poorer overall survival of lung cancer patients, especially those without lymph node metastasis.