HCCs exhibited underexpression of IKZF1 mRNA levels compared with their corresponding non-tumorous livers (Figure 1c); however, MDIG mRNA was expressed at high levels in HCC samples compared with the matched non-cancer liver tissue (Figure 1c), and a similar result was obtained in a TCGA cohort (Supplementary Figure 1c). The gene discussed is RIOX2; the disease is hepatocellular carcinoma.