For instance, overexpression of MDIG is associated with high metastatic potential, positive lymph node metastasis and shorter Overall Survival (OS) in gastric cancer patients.25, 26 However, a paradoxical effect of MDIG on cell growth and motility at different stages of neoplastic transformation in non-small cell lung cancer has also been suggested.31 MDIG overexpression was also correlated with poorer overall survival of lung cancer patients, especially those without lymph node metastasis. This evidence concerns the gene RIOX2 and metastatic malignant neoplasm in the lymph nodes.