Such effects may result from fundamental changes in lipid raft composition, persistent ER stress which, through three distinct ERS sensor proteins: ATF6 (activating transcription factor 6), PERK (protein kinase RNA-like endoplasmic reticulum kinase) and IRE1 (inositol-requiring trans-membrane kinase/endonuclease 1), activate the unfolded protein response (UPR), and disruption of the lipid-mediated crosstalk between cancer and stromal cells. Here, ATF6 is linked to cancer.