More specific tests, including extractable nuclear antigen (ENA) antibodies (e.g., anti-Scl70, SSA/Ro, SSB/La, RNP and Sm autoantibodies), and selected myositis antibodies (anti-Jo1, PL-7 and PL-12), are recommended only in selected cases [1]. The gene discussed is TRIM21; the disease is myositis disease.