BGP extract increased the susceptibility of the cancer cells to apoptosis upon PDT via decreasing the anti-apoptotic protein (Bcl-xL) and increasing the pro-apoptotic proteins (Bax, NOXA and cleaved caspase-3), which indicates that BGP extract enhanced PDT-induced death through the pathways associated with mitochondrial damage. The gene discussed is PMAIP1; the disease is cancer.