Decreased levels of DNA-PK were, on the contrary, found in the presence of the fusion protein between the Rho guanine nucleotide exchange factor (RhoGEF) and GTPase activating protein BCR and the non-receptor tyrosine kinase ABL1 (BCR-ABL1) in CML (Figure 2A, brown arrows) [77]. Here, PRKDC is linked to chronic myelogenous leukemia, BCR-ABL1 positive.