SAV1 and neoplasm: However, when the tumour suppressors NF2, LATS1/2, SAV1, RASSF are inactivated due to genetic mutation, fusion or deletion 13, YAP can translocate and accumulate in the nucleus and interact with transcription factor TEAD and initiate the gene transcription involved in anti‐apoptosis and proliferation, for example, that of CTGF and AREG.