Our proposed diagram of the regulation of YAP by the Hippo pathway and Rho/ROCK signaling in mesothelioma cells (Fig. 8) shows that the upstream tumour suppressor NF2 or RASSF can activate the Hippo core kinase cascade through phosphorylation of MST1/2 26, 44. The gene discussed is MST1; the disease is mesothelioma.