Considering the IL-17 biological function in Chagas disease, Guedes et al. [24] showed that the neutralization of IL-17 in mice BALB/c infected with T. cruzi has resulted in a higher recruitment of inflammatory cells to the cardiac tissue in the acute phase of the infection, leading to an increase in myocarditis and, consequently, premature death, despite the reduction of the local parasitism. This evidence concerns the gene IL17A and infection.