Infection with the PA14 ΔpopB mutant also induced mature IL-18 intracellular expression, but addition of TAK-242 (alone or in combination with MyD88i) appeared to significantly decrease its intracellular production (P < 0.01; Figure 4A and Supplementary Table 3), whereas MyD88i alone had no significant effect. This evidence concerns the gene IL18 and infection.