Des‐γ‐carboxyprothrombin is also an HCC‐associated antigen that is used to detect HCC, and its serum levels increase in 55–74% of patients with HCC; however, the measurement of des‐γ‐carboxyprothrombin level alone is not sufficient for early detection of HCC 16, 17. Here, DES is linked to hepatocellular carcinoma.