Although not approved for intravitreal use, off-label bevacizumab therapy rapidly became the most common intravitreal anti-VEGF therapy, and the Comparison of AMD Treatment Trials (CATT) study showed strong evidence that both bevacizumab and ranibizumab have similar efficacy for treating eyes with neovascular AMD, supporting the use of bevacizumab as an effective anti-VEGF therapy [25]. This evidence concerns the gene VEGFA and age-related macular degeneration.