NOS3 and cardiac hypertrophy: In 2007, a polymorphism case was reported for CSX by Jabrocka-Hybel et al.31 Suggesting that the polymorphisms of the angiotensin-converting enzyme gene and endothelial nitric oxide synthase gene was associated with left ventricular hypertrophy, the authors assessed the association between polymorphisms and left ventricular hypertrophy in patients with CSX and concluded that the presence of allele 4 of endothelial nitric oxide synthase (eNOS) gene intron 4 VNTR polymorphism could predispose to cardiac hypertrophy.